GLOBACAND 8 MG 28 F.C. TAB

About Candesartan CilexetilSAngiotensin || Antagonist Antihypertensive agentSMechanism of Action of Candesartan CilexetilSIt is a antagonist of angiotensin 2 at AT-1 receptor.It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all actions of angiotensin-2 such as 1.Vasoconstriction 2. Central and peripheral sympathetic stimulus 3. Release of aldosterone and adrenaline 4. Salt and water reabsorption 5.Central actions like thirst vasopressin release and growth promoting actions on heart and blood vessalsSIndications for Candesartan CilexetilSHypertensionSInteractions for Candesartan CilexetilSDiuretics and other antihypertensives: Increased risk of hypotension SLithium: Increased lithium blood level SNSAID: Decreased antihypertensive effect SPotassium sparing diuretics Potassium supplements: Increased risk of hyperkalemia