GLUCONORM 2 MG 30 TAB

ABOUT REPAGLINIDE MEGLITINIDE DERIVATIVE INSULIN SECRETAGOGUE ORAL ANTI-DIABETIC DRUG. MECHANISM OF ACTION OF REPAGLINIDE IT IS A QUICK AND SHORT ACTING ANTIDIABETIC DRUG WHICH EXERTS IT`S ACTION BY STIMULATING INSULIN RELEASE FROM ?-CELLS OF PANCREAS. IT ACTS BY BINDING TO SULFONYLUREA RECEPTOR AND TO OTHER DISTINCT RECEPTORS AND CLOSES ATP DEPENDENT POTASSIUM CHANNELS AND THUS CAUSES DEPOLARIZATION. THIS DEPOLARIZATION OF PANCREATIC ? CELLS CAUSES OPENING OF CA CHANNELS AND INCREASED CA INFLUX WHICH INDUCES INSULIN SECRETION. INDICATIONS FOR REPAGLINIDE NON-INSULIN DEPENDENT DIABETES MELLITUS (AS ADJUNCT TO DIET AND EXERCISE) INTERACTIONS FOR REPAGLINIDE KETOCONAZOLE MICONAZOLE AND ERYTHROMYCIN: METABOLISM OF REPAGLINIDE INHIBITED. TROGLITAZONE RIFAMPICIN BARBITURATES AND CARBAMAZEPINE: INCREASE METABOLISM OF REPAGLINIDE.