HOPDETOX 0.2 MG 20 F.C. TAB

Indication:Investigated for use/treatment in addictions and substance abuse. Pharmacodynamics: Lofexidine is an orally active imidazoline adrenergic alpha-2-receptor agonist; and is believed to have a high affinity for 2A receptor subtypes resulting in less anti-hypertensive activity than clonidine a non-selective alpha-2-receptor agonist. Hypotension may occur in susceptible subjects accompanied by a decrease in heart rate. Abrupt discontinuation of lofexidine has been in some cases associated with a transient increase in blood pressure to higher than pre-treatment levels. It selectively stimulates receptors in the brain that monitor catecholamine levels in the blood. These receptors close a negative feedback loop that begins with descending sympathetic nerves from the brain that control the production of catecholamines (epinephrine also known as adrenaline and norepinephrine) in the adrenal medulla.