IRINOTECAN MYLAN 100MG/5ML VIAL

ABOUT IRINOTECAN A TOPOISOMERASE 1 INHIBITOR NATURAL SOURCE (PLANT) DERIVATIVE SEMISYNTHETIC CAMPTOTHECIN ANALOGUE ANTINEOPLASTIC. MECHANISM OF ACTION OF IRINOTECAN BINDING OF IRINOTECAN AND ITS ACTIVE METABOLITE BIND TO THE TOPOISOMERASE 1 (WHICH CATALYZE RECOMBINATION REPAIR OF DNA AND ALSO REVERSIBLE SINGLE STRAND BREAKS IN DNA DURING DNA REPLICATION) AND FORM A TOPOISOMERASE1-DNA COMPLEX AND THIS PREVENTS RELEGATION OF THESE SINGLE STRAND BREAKS FINALLY CELL DEATH. INTERACTIONS FOR IRINOTECAN OTHER ANTINEOPLASTIC AGENTS: SIDE EFFECTS LIKE DIARRHOEA AND MYELOSUPPRESSION MAY BE EXACERBATED. DEXAMETHASONE: LYMPHOCYTOPENIA HAS BEEN OBSERVED WHEN COADMINISTERED. DIURETICS: BECAUSE OF POSSIBILITY OF CAUSING DEHYDRATION WITH DIARRHOEA CAUTION SHOULD BE OBSERVED IN THE USE OF IRINOTECAN WITH DIURETICS.