AMRIODIVASC 10/5 MG 15 TABS

Indication For the treatment of mild to moderate essential hypertension mild to moderate congestive heart failure and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial infarction and stable coronary disease. About Amlodipine Calcium Channel Blocker Anti hypertensive anti angina. Mechanism of Action of Amlodipine Amlodipine is a second generation dihydropyridine Ca channel blocker. It exerts it`s antihypertensive antianginal actions through blocking the influx of Ca ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium decrease peripheral resistance & reduce myocardial oxygen demand .It markedly relax arterioles and milder effects on veins. They do not compromise haemodynamics and cerebral and renal perfusion. Indications : 1.Hypertension 2.Prinzmetal`s angina 3.Stable angina