KELFER 500 MG 50 CAPS

Description Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result erythropoiesis the production of new red blood cells is impaired. FDA approved on October 14 2011. Indication : Deferiprone is indicated in thalassemia syndromes when first line chelation agents are not adequate to treat transfusional iron overload. Mechanism of action Deferiprone " is an iron chelator that binds to ferric ions (iron III) and forms a 3:1 (deferiprone:iron) stable complex and is then eliminated in the urine. Deferiprone is more selective for iron in which other metals such as zinc copper and aluminum have a lower affinity for deferiprone.