PROPOFOL 1% FRESENIUS EMLSION FOR I.V. INF. OR INJ

About Propofol A short-acting intravenous hypnotic General Anesthetia(Intravenous induction agent). Mechanism of Action of Propofol It excites inhibitory and inhibits excitatory synapsis by binding ligand-gated ion channels specially post-synaptic GABA receptors. It cause CNS depression and calcium channel mediated cardiac depression. Indications for Propofol 1. Induction/maintenance of anesthesia 2. Conscious sedation Interactions for Propofol Opioids muscle relaxants / neuromuscular blockers: Increased anaesthesia increased respiratory depression (opioids) increased neuromuscular blockade. Midazolam thiopental fentanyl: Increased hypnosis. Nitrous oxide halothane isoflurane: Decrease dose.