TROPIRESTEN 5MG/5ML 5 I.V. AMPS

5-HT3 ANTAGONIST.ANTI-EMETIC About Tropisetron Selective 5HT3 receptor antagonist indole derivative Antiemetic antinauseant. Mechanism of Action of Tropisetron Tropisetron is a selective 5HT3 receptor antagonist. 5HT3 receptors are present in vagal nerve terminals and chemoreceptor trigger zone of area postrema of the brain. Cytotoxic chemotherapy is associated with release of Serotonin from Enterochromaffin cells in the small intestine. Serotonin triggers vomiting through 5HT3 vagal receptor that activates the vomiting reflex. Since Tropisetron is a 5HT3 receptor antagonist it is indicated for the prevention of nausea and vomiting associated in chemotherapy. Indications for Tropisetron 1.Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy.